Foot and Ankle Surgery
Volume 16, Issue 3 , Pages e51-e54 , September 2010

Alveolar rhabdomyosarcoma originating between the fourth and fifth metatarsal—Case report and literature review

  • J.C. Bolger, MB, BCh, BAO

      Affiliations

    • Department of Surgery, Beaumont University Hospital, Beaumont, Dublin 9, Ireland
    • Corresponding Author InformationCorresponding author. Tel.: +353 1 8093000; fax: +353 1 8376982.
    • ,
  • J.C. Walsh, MCh, MRCSI

      Affiliations

    • Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland
    • ,
  • R.E. Hughes, MB, BCh, BAO

      Affiliations

    • Mater Misericordiae Hospital, Eccles Street, Dublin, Ireland
    • ,
  • S.J. Eustace, MB, MRCPI, FFR, FRCR, FFSEM

      Affiliations

    • Mater Misericordiae Hospital, Eccles Street, Dublin, Ireland
    • Department of Orthopaedic Surgery, Cappagh National Orthopaedic Hospital, Finglas, Dublin, Ireland
    • ,
  • P. Harrington, MCh, FRCSI

      Affiliations

    • Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland

Received 21 October 2009 ,Revised 16 February 2010 ,Accepted 2 March 2010.

References 

  1. Lawrence W, Gehan EA, Hays DM, Beltangady M, Maurer HM. Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS-II). J Clin Oncol. 1987;5(1):46–54
  2. Meyer WH, Spunt SL. Soft tissue sarcomas of childhood. Cancer Treat Rev. 2004;30:269–280
  3. Gallego Melcon S, Sánchez de Toledo Codina J. Molecular biology of rhabdomyosarcoma. Clin Transl Oncol. 2007;9:415–419
  4. Parham DM, Ellison DA. Rhabdomyosarcoma in adults and children: an update. Arch Pathol Lab Med. 2006;130:1454–1465
  5. Neville HL, Andrassy RJ, Lobe TE, et al. Preoperative staging, prognostic factors, and outcome for extremity rhabdomyosarcoma: a preliminary report from the Intergroup Rhabdomyosarcoma Study IV (1991–1997). J Pediatr Surg. 2000;35:317–321
  6. Raney RB, Meza J, Anderson JR, et al. Treatment of children and adolescents with localised parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978–1997. Med Pediatr Oncol. 2002;38:22–32
  7. Crist W, Gehan EA, Ragab AH, et al. The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 1995;13:610–630
  8. Charytonowicz E, Cordon-Cardo D, Matushansky I, Ziman M. Alveolar rhabdomyosarcoma: is the cell or origin a mesenchymal stem cell?. Cancer Lett. 2009;279:126–136
  9. Wang NP, Marx J, McNutt MA, Rutledge JC, Gown AM. Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol. 1995;147:1799–1810
  10. Cessna MH, Zhou H, Perkins SL, et al. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol. 2001;25:1150–1157
  11. Epstein JA, Lam P, Jepeal L, Maas RL, Shapiro DN. Pax3 inhibits myogenic differentiation of cultured myoblast stem cells. J Biol Chem. 1995;270:11719–11722
  12. Lamey TM, Koenders A, Ziman M. Pax genes in myogenesis: alternate transcripts add complexity. Histol Histopathol. 2004;19:1289–1300
  13. Lang D, Lu MM, Huang L, et al. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 2005;433:884–887
  14. Mercado GE, Barr FG. Fusions involving Pax and Fox genes in the molecular pathogenesis of alveolar rhabdomyosarcom: recent advances. Curr Mol Med. 2007;7:47–61
  15. Kelly KM, Womer RB, Sorensen PH, Xiong QB, Barr FG. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol. 1997;15:1831–1836
  16. McCarville MB, Christie R, Daw NC, Spunt SL, Kaste SC. PET/CT in the evaluation of childhood sarcomas. Am J Roentgenol. 2005;184:1293–1304
  17. Kilpatrick SE, Cappellari JO, Bos GD, et al. Is fine needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of a sarcoma?. Am J Clin Pathol. 2001;115:59–68
  18. Völker T, Denecke T, Steffen I, et al. Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial. J Clin Oncol. 2007;25(34):5435–5441
  19. Willman JH, White K, Coffin CM. Pediatric core needle biopsy: strengths and limitations in evaluation of masses. Pediatr Dev Pathol. 2001;4:46–52
  20. Lietman SA. Current management of soft tissue sarcomas. Curr Opin Orthop. 2001;12:505–508
  21. Leaphart C, Rodeberg D. Pediatric surgical oncology: management of rhabdomyosarcoma. Surg Oncol. 2007;16(3):173–185
  22. Hays DM, Lawrence W, Wharam M, et al. Primary reexcision for patients with ‘microscopic residual’ tumor following initial excision of sarcomas of trunk and extremity sites. J Pediatr Surg. 1989;24(1):5–10
  23. Schalow EL, Broecker BH. Role of surgery in children with rhabdomyosarcoma. Med Pediatr Oncol. 2003;41:1–6
  24. Oberlin O, Rey A, Lyden E, et al. Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups. J Clin Oncol. 2008;26:2384–2389

PII: S1268-7731(10)00035-4

doi: 10.1016/j.fas.2010.03.003

Foot and Ankle Surgery
Volume 16, Issue 3 , Pages e51-e54 , September 2010

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