Foot and Ankle Surgery
Volume 14, Issue 3 , Pages 145-152 , 2008

A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc®) in patients with symptomatic ankle (talo-crural) osteoarthritis

  • Angelique G.H. Witteveen, M.D.

      Affiliations

    • Orthopaedic Research Centre Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author.
    • ,
  • Sandro Giannini, M.D.

      Affiliations

    • IX Divisione di Ortopedia, Instituto Ortopedici Rizzoli, Bologna, Italy
    • ,
  • Giulio Guido, M.D., Ph.D.

      Affiliations

    • I Ortopedia Universitaria, Ospedale Santa Chiara, Pisa, Italy
    • ,
  • Joerg Jerosch, M.D., Ph.D.

      Affiliations

    • Johanna Etienne Krankenhaus, Klinik für Orthopadie, Neuss, Germany
    • ,
  • Heinz Lohrer, M.D.

      Affiliations

    • Sportmedizinisches Institut, Frankfurt am Main, Germany
    • ,
  • Francesca Vannini, M.D.

      Affiliations

    • IX Divisione di Ortopedia, Instituto Ortopedici Rizzoli, Bologna, Italy
    • ,
  • Leonardo Donati, M.D.

      Affiliations

    • I Ortopedia Universitaria, Ospedale Santa Chiara, Pisa, Italy
    • ,
  • Axel Schulz, M.D.

      Affiliations

    • Orthopaedic Research Centre Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    • Johanna Etienne Krankenhaus, Klinik für Orthopadie, Neuss, Germany
    • ,
  • Jakob Scholl, M.D.

      Affiliations

    • Sportmedizinisches Institut, Frankfurt am Main, Germany
    • ,
  • Inger N. Sierevelt, M.Sc.

      Affiliations

    • Orthopaedic Research Centre Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    • ,
  • C. Niek van Dijk, M.D., Ph.D.

      Affiliations

    • Orthopaedic Research Centre Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

Received 10 July 2007 ,Revised 20 November 2007 ,Accepted 2 January 2008.

References 

  1. Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis. Clin Orthop Relat Res. 2004;Suppl. 427:S6–S15
  2. Cushnaghan J, Dieppe P. Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann Rheum Dis. 1991;50:8–13
  3. Saltzman CL, Salamon ML, Blanchard GM, Huff T, Hayes A, Buckwalter JA, et al. Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopedic center. Iowa Orthop J. 2005;25:44–46
  4. Agel J, Coetzee JC, Sangeorzan BJ, Roberts MM, Hansen ST. Functional limitations of patients with end-stage ankle arthrosis. Foot Ankle Int. 2005;26:537–539
  5. van Dijk CN, Tol JL, Verheyen CC. A prospective study of prognostic factors concerning the outcome of arthroscopic surgery for anterior ankle impingement. Am J Sports Med. 1997;25:737–745
  6. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines . Recommendations for the medical management of osteoarthritis of the hip and the knee: 2000 update. Arthritis Rheum. 2000;43:1905–1915
  7. Pendleton A, Arden N, Dougados M, Doherty M, Bannwarth B, Bijlsma JW, et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2000;59:936–944
  8. Pelletier JP, Martel-Pelletier J. The pathophysiology of osteoarthritis and the implication of the use of hyaluronan and hylan as therapeutic agents in viscosupplementation. J Rheumatol Suppl. 1993;39:19–24
  9. Weiss C, Band P. Musculoskeletal applications of hyaluronan and hylan. Potential uses in the foot and ankle. Clin Podiatr Med Surg. 1995;12:497–517
  10. Salk RS, Chang TJ, D’Costa WF, Soomekh DJ, Grogan KA. Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study. J Bone Joint Surg Am. 2006;88:295–302
  11. Sun SF, Chou YJ, Hsu CW, Hwang CW, Hsu PT, Wang JL, et al. Efficacy of intra-articular hyaluronic acid in patients with osteoarthritis of the ankle: a prospective study. Osteoarthritis Cartilage. 2006;14:867–874
  12. Conrozier T, Bertin P, Mathieu P, Charlot J, Bailleul F, Treves R, et al. Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study. Clin Exp Rheumatol. 2003;21:605–610
  13. Migliore A, Tormenta S, Martin Martin LS, Iannessi F, Massafra U, Carloni E, et al. The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up. Clin Rheumatol. 2006;25:389–393
  14. van Dijk, CN. Ankle joint arthroscopy. In: Surgical techniques in orthopaedics and traumatology. Editions Scientifiques et Médicales Elsevier SAS (Paris), 2001: 1–6.
  15. Domsic RT, Saltzman CL. Ankle osteoarthritis scale. Foot Ankle Int. 1998;19:466–471
  16. Kemper F, Gebhardt U, Meng T, Murray C. Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice. Curr Med Res Opin. 2005;21:1261–1269
  17. Synvisc Product Label (USA).
  18. Kelly MA, Kurzweil PR, Moskowitz RW. Intra-articular hyaluronans in knee osteoarthritis: rationale and practical considerations. Am J Orthop. 2004;33:15–22
  19. Hyalgan Study GroupAltman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a 1 year placebo-controlled trial. J Rheumatol. 1998;25:2203–2212
  20. Brandt KD, Block JA, Michalski JP, Moreland LW, Caldwell JR, Lavin PT. Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. ORTHOVISC Study Group. Clin Orthop Relat Res. 2001;385:130–143
  21. Dougados M, Nguyen M, Listrat V, Amor B. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial. Osteoarthritis Cartilage. 1993;1:97–103
  22. Henderson EB, Smith EC, Pegley F, Blake DR. Intra-articular injections of 750kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy. Ann Rheum Dis. 1994;53:529–534
  23. Bagga H, Burkhardt D, Sambrook P, March L. Long term effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006;33:946–950

PII: S1268-7731(08)00002-7

doi: 10.1016/j.fas.2008.01.001

Foot and Ankle Surgery
Volume 14, Issue 3 , Pages 145-152 , 2008

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